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10.1519/JSC.0000000000001437 33

In a study by Frangoul et al., CRISPR-Cas9 was used to disrupt an erythroid-specific enhancer of BCL11A in CD34 + hematopoietic stem and progenitor cells (HSPCs) ( 4 Future perspectives and outlook Erythrocytes, long viewed primarily as passive oxygen carriers, are now recognized as active participants in sensing and responding to oxygen fluctuations

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Delays in diagnosis and subsequent initiation in treatment of pernicious anaemia have been shown to increase the risk of irreversible neurological damage involving both the central and peripheral nervous system, resulting in permanent symptoms, such as peripheral neuropathy, cognitive impairment and damage to the spinal cord (known as subacute combined degeneration of the spinal cord)[9,16]

The amount is flexible and determines the final concentration